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MLOC_17646.3 protein (Hordeum vulgare) - STRING interaction network
"MLOC_17646.3" - DNA topoisomerase in Hordeum vulgare
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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MLOC_17646.3DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand (734 aa)    
Predicted Functional Partners:
MLOC_54481.2
Uncharacterized protein (450 aa)
     
  0.986
MLOC_53883.5
DNA topoisomerase (918 aa)
     
 
0.976
MLOC_64534.1
Uncharacterized protein (998 aa)
   
  0.854
MLOC_82021.4
Uncharacterized protein (343 aa)
   
  0.850
MLOC_50110.1
Uncharacterized protein (353 aa)
   
  0.850
MLOC_25539.1
Uncharacterized protein (152 aa)
   
  0.850
MLOC_73716.2
Uncharacterized protein (418 aa)
     
 
  0.826
MLOC_26320.1
Uncharacterized protein (523 aa)
     
 
  0.825
MLOC_53917.1
Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (940 aa)
     
  0.809
MLOC_10576.1
Replication protein A subunit; Component of the replication protein A complex (RPA) required for DNA recombination, repair and replication. The activity of RPA is mediated by single-stranded DNA binding and protein interactions. Probably involved in repair of double-strand DNA breaks (DSBs) induced by genotoxic stresses (877 aa)
     
  0.809
Your Current Organism:
Hordeum vulgare
NCBI taxonomy Id: 4513
Other names: H. vulgare, Hordeum vulgare, Hordeum vulgare L., barley
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