node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pnec_0289 | fmt | Pnec_0289 | Pnec_1777 | TIGRFAM: succinic semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: pnu:Pnuc_0263 succinic semialdehyde dehydrogenase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.899 |
Pnec_0289 | metG | Pnec_0289 | Pnec_1209 | TIGRFAM: succinic semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: pnu:Pnuc_0263 succinic semialdehyde dehydrogenase. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.422 |
Pnec_0386 | Pnec_0438 | Pnec_0386 | Pnec_0438 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: formyl transferase domain protein; KEGG: pnu:Pnuc_0432 hypothetical protein. | 0.905 |
Pnec_0386 | Pnec_1688 | Pnec_0386 | Pnec_1688 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
Pnec_0386 | Pnec_1689 | Pnec_0386 | Pnec_1689 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: homocysteine S-methyltransferase; KEGG: pnu:Pnuc_1980 methionine synthase. | 0.910 |
Pnec_0386 | fmt | Pnec_0386 | Pnec_1777 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.905 |
Pnec_0386 | glyA | Pnec_0386 | Pnec_0307 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.928 |
Pnec_0386 | purN | Pnec_0386 | Pnec_1456 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.923 |
Pnec_0438 | Pnec_0386 | Pnec_0438 | Pnec_0386 | PFAM: formyl transferase domain protein; KEGG: pnu:Pnuc_0432 hypothetical protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.905 |
Pnec_0438 | Pnec_1688 | Pnec_0438 | Pnec_1688 | PFAM: formyl transferase domain protein; KEGG: pnu:Pnuc_0432 hypothetical protein. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
Pnec_0438 | Pnec_1689 | Pnec_0438 | Pnec_1689 | PFAM: formyl transferase domain protein; KEGG: pnu:Pnuc_0432 hypothetical protein. | PFAM: homocysteine S-methyltransferase; KEGG: pnu:Pnuc_1980 methionine synthase. | 0.900 |
Pnec_0438 | def | Pnec_0438 | Pnec_1778 | PFAM: formyl transferase domain protein; KEGG: pnu:Pnuc_0432 hypothetical protein. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.671 |
Pnec_0438 | fmt | Pnec_0438 | Pnec_1777 | PFAM: formyl transferase domain protein; KEGG: pnu:Pnuc_0432 hypothetical protein. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.918 |
Pnec_0438 | folD | Pnec_0438 | Pnec_0703 | PFAM: formyl transferase domain protein; KEGG: pnu:Pnuc_0432 hypothetical protein. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.932 |
Pnec_0438 | glyA | Pnec_0438 | Pnec_0307 | PFAM: formyl transferase domain protein; KEGG: pnu:Pnuc_0432 hypothetical protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.903 |
Pnec_0438 | metG | Pnec_0438 | Pnec_1209 | PFAM: formyl transferase domain protein; KEGG: pnu:Pnuc_0432 hypothetical protein. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.938 |
Pnec_0438 | purN | Pnec_0438 | Pnec_1456 | PFAM: formyl transferase domain protein; KEGG: pnu:Pnuc_0432 hypothetical protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.904 |
Pnec_1688 | Pnec_0386 | Pnec_1688 | Pnec_0386 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.900 |
Pnec_1688 | Pnec_0438 | Pnec_1688 | Pnec_0438 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: formyl transferase domain protein; KEGG: pnu:Pnuc_0432 hypothetical protein. | 0.900 |
Pnec_1688 | Pnec_1689 | Pnec_1688 | Pnec_1689 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: homocysteine S-methyltransferase; KEGG: pnu:Pnuc_1980 methionine synthase. | 0.999 |