STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
linB1,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase LinB; Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity since not only monochloroalkanes (C3 to C10) but also dichloroalkanes (> C3), bromoalkanes, and chlorinated aliphatic alcohols are good substrates. Shows almost no activity with 1,2-dichloroethane, but very high activity with the brominated analog. Is involved in the degradation of the important environmental pollutant gam [...] (296 aa)    
Predicted Functional Partners:
linX
2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase LinX; Catalyzes the degradation of 2,5-dichloro-2,5-cyclohexadiene- 1,4-diol (2,5-DDOL) into 2,5-dichlorohydroquinone (2,5-DCHQ) in vitro. LinX appears not to be involved in gamma-hexachlorocyclohexane (gamma- HCH) degradation pathway, in contrast to LinC which has the same enzymatic activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 0.945
linC
2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase LinC; Catalyzes the dehydrogenation of 2,5-dichloro-2,5- cyclohexadiene-1,4-diol (2,5-DDOL) to 2,5-dichlorohydroquinone (2,5- DCHQ), a step in the degradation of gamma-hexachlorocyclohexane (gamma- HCH or lindane). Has an essential role in this assimilation pathway that allows S.japonicum UT26 to grow on gamma-HCH as the sole source of carbon and energy.
   
 0.944
linA
Gamma-hexachlorocyclohexane dehydrochlorinase LinA; Catalyzes the conversion of the important environmental pollutant gamma-hexachlorocyclohexane (gamma-HCH or lindane) to 1,3,4,6-tetrachloro-1,4-cyclohexadiene (1,4-TCDN) via gamma- pentachlorocyclohexene (gamma-PCCH), proceeding by two successive 1,2- anti conformationally dependent dehydrochlorinations. Also shows activity with alpha- and delta-HCH, giving alpha- and delta- PCCH respectively, but not with the beta isomer. Is involved in the degradation pathway that allows S.japonicum UT26 to grow on gamma- HCH as the sole source of c [...]
     
 0.940
adh-5
Zn-dependent alcohol dehydrogenase; Class III; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.
   
  0.906
adh-6
Zn-dependent alcohol dehydrogenase, class III.
   
  0.906
adh
Zn-dependent alcohol dehydrogenase.
    
  0.905
BAI98936.1
Pyrrolo-quinoline quinone (PQQ)-linked alcohol dehydrogenase.
     
  0.900
linF
Maleylacetate reductase LinF; Catalyzes the NADH-dependent reduction of maleylacetate to beta-ketoadipate, a step in the degradation of gamma- hexachlorocyclohexane (gamma-HCH or lindane). Has an essential role in this assimilation pathway that allows S.japonicum UT26 to grow on gamma-HCH as the sole source of carbon and energy.
      
 0.706
linJ
acetyl-CoA C-acetyltransferase LinJ; Gamma-hexachlorocyclohexane degradation; Belongs to the thiolase-like superfamily. Thiolase family.
     
 0.694
BAI98872.1
Putative flavin-containing monooxygenase; Putative flavoprotein involved in K+ transport.
 
 
 0.586
Your Current Organism:
Sphingobium japonicum
NCBI taxonomy Id: 452662
Other names: S. japonicum UT26S, Sphingobium japonicum UT26, Sphingobium japonicum UT26S, Sphingobium japonicum str. UT26S, Sphingobium japonicum strain UT26S
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