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arc protein (Arthrobacter chlorophenolicus) - STRING interaction network
"arc" - Proteasome-associated ATPase in Arthrobacter chlorophenolicus
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Predicted Interactions
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textmining
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protein homology
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arcProteasome-associated ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a ’key in a lock’ to induce gate opening and therefore regulate proteolysis (583 aa)    
Predicted Functional Partners:
pafA
Pup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (454 aa)
 
 
  0.978
Achl_1917
PFAM- protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG- art-Arth_2174 protein of unknown function DUF245 domain protein (539 aa)
 
     
  0.975
prcB
Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation; Belongs to the peptidase T1B family (273 aa)
 
 
  0.961
prcA
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation; Belongs to the peptidase T1A family (236 aa)
 
 
  0.950
Achl_3761
PFAM- GCN5-related N-acetyltransferase; AAA ATPase central domain protein; SMART- AAA ATPase; KEGG- art-Arth_3981 AAA ATPase, central domain protein; Belongs to the AAA ATPase family (438 aa)
 
 
 
0.891
pup
Prokaryotic ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (67 aa)
 
     
  0.858
Achl_1915
tRNA (adenine(58)-N(1))-methyltransferase TrmI; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA (354 aa)
 
        0.801
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family (504 aa)
 
 
 
  0.784
Achl_0833
KEGG- art-Arth_0683 hypothetical protein (215 aa)
   
     
  0.755
Achl_1914
Zinc metalloprotease; PFAM- peptidase M50; KEGG- art-Arth_2171 peptidase M50; Belongs to the peptidase M50B family (387 aa)
 
        0.698
Your Current Organism:
Arthrobacter chlorophenolicus
NCBI taxonomy Id: 452863
Other names: A. chlorophenolicus A6, Arthrobacter chlorophenolicus, Arthrobacter chlorophenolicus A6, Arthrobacter chlorophenolicus str. A6, Arthrobacter chlorophenolicus strain A6
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