node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Achl_0143 | Achl_0442 | Achl_0143 | Achl_0442 | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: aav:Aave_3759 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | Tartrate dehydrogenase; KEGG: rha:RHA1_ro04803 3-isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 0.821 |
Achl_0143 | Achl_0720 | Achl_0143 | Achl_0720 | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: aav:Aave_3759 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: aau:AAur_2010 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | 0.503 |
Achl_0143 | Achl_2278 | Achl_0143 | Achl_2278 | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: aav:Aave_3759 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; acetolactate synthase small subunit; KEGG: art:Arth_2538 acetolactate synthase 3 regulatory subunit. | 0.873 |
Achl_0143 | ilvC | Achl_0143 | Achl_2277 | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: aav:Aave_3759 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.965 |
Achl_0143 | leuA | Achl_0143 | Achl_1963 | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: aav:Aave_3759 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.839 |
Achl_0143 | leuB | Achl_0143 | Achl_2268 | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: aav:Aave_3759 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.811 |
Achl_0143 | leuC | Achl_0143 | Achl_2256 | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: aav:Aave_3759 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.877 |
Achl_0143 | leuD | Achl_0143 | Achl_2255 | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: aav:Aave_3759 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.838 |
Achl_0442 | Achl_0143 | Achl_0442 | Achl_0143 | Tartrate dehydrogenase; KEGG: rha:RHA1_ro04803 3-isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: aav:Aave_3759 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.821 |
Achl_0442 | Achl_2278 | Achl_0442 | Achl_2278 | Tartrate dehydrogenase; KEGG: rha:RHA1_ro04803 3-isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; acetolactate synthase small subunit; KEGG: art:Arth_2538 acetolactate synthase 3 regulatory subunit. | 0.986 |
Achl_0442 | ilvC | Achl_0442 | Achl_2277 | Tartrate dehydrogenase; KEGG: rha:RHA1_ro04803 3-isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.896 |
Achl_0442 | ilvD | Achl_0442 | Achl_2280 | Tartrate dehydrogenase; KEGG: rha:RHA1_ro04803 3-isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | KEGG: aau:AAur_2510 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.767 |
Achl_0442 | ilvD-2 | Achl_0442 | Achl_3368 | Tartrate dehydrogenase; KEGG: rha:RHA1_ro04803 3-isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | KEGG: aau:AAur_0356 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.731 |
Achl_0442 | leuA | Achl_0442 | Achl_1963 | Tartrate dehydrogenase; KEGG: rha:RHA1_ro04803 3-isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.809 |
Achl_0442 | leuC | Achl_0442 | Achl_2256 | Tartrate dehydrogenase; KEGG: rha:RHA1_ro04803 3-isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.942 |
Achl_0442 | leuD | Achl_0442 | Achl_2255 | Tartrate dehydrogenase; KEGG: rha:RHA1_ro04803 3-isopropylmalate dehydrogenase; TIGRFAM: tartrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.920 |
Achl_0720 | Achl_0143 | Achl_0720 | Achl_0143 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: aau:AAur_2010 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: aav:Aave_3759 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.503 |
Achl_0720 | Achl_2278 | Achl_0720 | Achl_2278 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: aau:AAur_2010 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; acetolactate synthase small subunit; KEGG: art:Arth_2538 acetolactate synthase 3 regulatory subunit. | 0.980 |
Achl_0720 | ilvC | Achl_0720 | Achl_2277 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: aau:AAur_2010 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.682 |
Achl_0720 | ilvD | Achl_0720 | Achl_2280 | PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: aau:AAur_2010 pyruvate dehydrogenase; Belongs to the TPP enzyme family. | KEGG: aau:AAur_2510 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.517 |