STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
psmB1Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (198 aa)    
Predicted Functional Partners:
pan
26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]
  
 0.905
psmB2
Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
  
 
0.905
psmA
Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.848
rpl40e
PFAM: Ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.758
Igni_0617
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; HI0933 family protein.
       0.655
Igni_0618
Hypothetical protein.
       0.655
Igni_0615
Exonuclease of the beta-lactamase fold involved in RNA processing-like protein.
  
    0.636
Igni_0619
PFAM: putative RNA methylase; Methyltransferase type 11.
       0.606
Igni_0620
PFAM: NAD(P)H dehydrogenase (quinone); NADPH-dependent FMN reductase.
       0.606
Igni_0994
PFAM: AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; Belongs to the AAA ATPase family.
 
 0.588
Your Current Organism:
Ignicoccus hospitalis
NCBI taxonomy Id: 453591
Other names: I. hospitalis KIN4/I, Ignicoccus hospitalis DSM 18386, Ignicoccus hospitalis JCM 14125, Ignicoccus hospitalis KIN4/I, Ignicoccus hospitalis str. KIN4/I, Ignicoccus hospitalis strain KIN4/I
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