STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dysDeoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (319 aa)    
Predicted Functional Partners:
eIF5A
Translation initiation factor 5A (eIF-5A); Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.
 
 
 0.978
Igni_0630
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB.
       0.644
folE
PFAM: GTP cyclohydrolase I.
  
  
 0.594
Igni_0628
PFAM: oxidoreductase domain protein; Alcohol dehydrogenase, zinc-binding domain protein.
       0.576
Igni_0629
Hypothetical protein.
       0.576
tiaS
DNA-binding protein containing a Zn-ribbon domain-like protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
       0.566
top6A
DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family.
     
 0.564
Igni_1371
Agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; Belongs to the arginase family.
 
   
 0.560
rpl10e
PFAM: Ribosomal protein L10E; Belongs to the universal ribosomal protein uL16 family.
 
    0.509
flpA
rRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
  
  
 0.494
Your Current Organism:
Ignicoccus hospitalis
NCBI taxonomy Id: 453591
Other names: I. hospitalis KIN4/I, Ignicoccus hospitalis DSM 18386, Ignicoccus hospitalis JCM 14125, Ignicoccus hospitalis KIN4/I, Ignicoccus hospitalis str. KIN4/I, Ignicoccus hospitalis strain KIN4/I
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.