node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Igni_0542 | radA | Igni_0542 | Igni_1006 | PFAM: NADH-ubiquinone oxidoreductase, chain 49kDa; NADH dehydrogenase (ubiquinone), 30 kDa subunit. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.884 |
Igni_0542 | topA | Igni_0542 | Igni_0007 | PFAM: NADH-ubiquinone oxidoreductase, chain 49kDa; NADH dehydrogenase (ubiquinone), 30 kDa subunit. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.524 |
Igni_0953 | Igni_1062 | Igni_0953 | Igni_1062 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | 0.921 |
Igni_0953 | Igni_1385 | Igni_0953 | Igni_1385 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | PFAM: SMC domain protein; Rad50 zinc hook; SMART: AAA ATPase. | 0.812 |
Igni_0953 | fen | Igni_0953 | Igni_0691 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.782 |
Igni_0953 | mre11 | Igni_0953 | Igni_0278 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.906 |
Igni_0953 | pcn | Igni_0953 | Igni_0610 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA polymerase sliding clamp subunit A; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.827 |
Igni_0953 | pcn-3 | Igni_0953 | Igni_0854 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.827 |
Igni_0953 | radA | Igni_0953 | Igni_1006 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.944 |
Igni_0953 | topA | Igni_0953 | Igni_0007 | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.905 |
Igni_1062 | Igni_0953 | Igni_1062 | Igni_0953 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | 0.921 |
Igni_1062 | Igni_1385 | Igni_1062 | Igni_1385 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | PFAM: SMC domain protein; Rad50 zinc hook; SMART: AAA ATPase. | 0.670 |
Igni_1062 | fen | Igni_1062 | Igni_0691 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] | 0.941 |
Igni_1062 | mre11 | Igni_1062 | Igni_0278 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.719 |
Igni_1062 | pcn | Igni_1062 | Igni_0610 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | DNA polymerase sliding clamp subunit A; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.664 |
Igni_1062 | pcn-3 | Igni_1062 | Igni_0854 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.736 |
Igni_1062 | radA | Igni_1062 | Igni_1006 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.843 |
Igni_1062 | top6A | Igni_1062 | Igni_1053 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.684 |
Igni_1062 | topA | Igni_1062 | Igni_0007 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.946 |
Igni_1385 | Igni_0953 | Igni_1385 | Igni_0953 | PFAM: SMC domain protein; Rad50 zinc hook; SMART: AAA ATPase. | PFAM: nucleic acid binding, OB-fold, tRNA/helicase-type. | 0.812 |