node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Igni_1052 | Igni_1054 | Igni_1052 | Igni_1054 | Hypothetical protein. | Hypothetical protein. | 0.464 |
Igni_1052 | Igni_1055 | Igni_1052 | Igni_1055 | Hypothetical protein. | Hypothetical protein. | 0.442 |
Igni_1052 | nnrD | Igni_1052 | Igni_1056 | Hypothetical protein. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.442 |
Igni_1052 | top6A | Igni_1052 | Igni_1053 | Hypothetical protein. | DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.598 |
Igni_1054 | Igni_1052 | Igni_1054 | Igni_1052 | Hypothetical protein. | Hypothetical protein. | 0.464 |
Igni_1054 | Igni_1055 | Igni_1054 | Igni_1055 | Hypothetical protein. | Hypothetical protein. | 0.732 |
Igni_1054 | nnrD | Igni_1054 | Igni_1056 | Hypothetical protein. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.732 |
Igni_1054 | top6A | Igni_1054 | Igni_1053 | Hypothetical protein. | DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.588 |
Igni_1055 | Igni_1052 | Igni_1055 | Igni_1052 | Hypothetical protein. | Hypothetical protein. | 0.442 |
Igni_1055 | Igni_1054 | Igni_1055 | Igni_1054 | Hypothetical protein. | Hypothetical protein. | 0.732 |
Igni_1055 | nnrD | Igni_1055 | Igni_1056 | Hypothetical protein. | Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] | 0.773 |
Igni_1055 | top6A | Igni_1055 | Igni_1053 | Hypothetical protein. | DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.558 |
Igni_1062 | mre11 | Igni_1062 | Igni_0278 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.719 |
Igni_1062 | radA | Igni_1062 | Igni_1006 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.843 |
Igni_1062 | top6A | Igni_1062 | Igni_1053 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.684 |
Igni_1062 | top6B | Igni_1062 | Igni_1090 | PFAM: ERCC4 domain protein; SMART: Helix-hairpin-helix DNA-binding, class 1. | DNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | 0.524 |
dnaG | radA | Igni_0061 | Igni_1006 | TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.443 |
dnaG | top6A | Igni_0061 | Igni_1053 | TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.579 |
dnaG | top6B | Igni_0061 | Igni_1090 | TOPRIM domain protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | 0.543 |
dys | top6A | Igni_0631 | Igni_1053 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. | DNA topoisomerase (ATP-hydrolyzing); Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.564 |