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hisD protein (Methanococcus voltae) - STRING interaction network
"hisD" - Histidinol dehydrogenase in Methanococcus voltae
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (425 aa)    
Predicted Functional Partners:
hisB
KEGG- ppd-Ppro_3040 imidazoleglycerol-phosphate dehydratase; PFAM- imidazoleglycerol-phosphate dehydratase (190 aa)
 
  0.999
hisC
KEGG- dal-Dalk_0935 histidinol-phosphate aminotransferase; TIGRFAM- histidinol-phosphate aminotransferase; PFAM- aminotransferase class I and II; aminotransferase class V (370 aa)
 
  0.998
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity; Belongs to the ATP phosphoribosyltransferase family. Long subfamily (293 aa)
 
  0.998
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (283 aa)
 
  0.995
hisA
TIGRFAM- phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG- gur-Gura_4054 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM- histidine biosynthesis protein (242 aa)
   
  0.990
hisE
KEGG- gem-GM21_3794 phosphoribosyl-ATP diphosphatase; TIGRFAM- phosphoribosyl-ATP diphosphatase; PFAM- phosphoribosyl-ATP pyrophosphohydrolase (100 aa)
 
   
  0.982
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (127 aa)
 
   
  0.963
Mvol_1693
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (213 aa)
   
  0.952
Mvol_0236
PFAM- histidine biosynthesis protein; KEGG- abu-Abu_0690 imidazoleglycerol phosphate synthase, cyclase subunit; Belongs to the HisA/HisF family (251 aa)
 
  0.934
Mvol_0235
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (231 aa)
   
  0.880
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
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