• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
purO protein (Methanococcus voltae) - STRING interaction network
"purO" - IMP cyclohydrolase in Methanococcus voltae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purOIMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP (209 aa)    
Predicted Functional Partners:
purP
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5’-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5’- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5’-monophosphate (FAICAR) in the absence of folates (361 aa)
       
  0.991
guaB
Inosine-5’-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth; Belongs to the IMPDH/GMPR family (498 aa)
 
   
  0.932
surE
5’-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5’-monophosphates; Belongs to the SurE nucleotidase family (269 aa)
   
   
    0.914
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (338 aa)
         
  0.912
Mvol_1641
PFAM- PfkB domain protein; KEGG- hha-Hhal_1195 ribokinase-like domain-containing protein; Belongs to the carbohydrate kinase PfkB family (316 aa)
         
    0.900
Mvol_1071
Phosphoesterase; KEGG- Ser/Thr protein phosphatase family protein; K07095; TIGRFAM- phosphodiesterase, MJ0936 family; PFAM- metallophosphoesterase (209 aa)
 
     
  0.742
purC
TIGRFAM- phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG- nam-NAMH_0651 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM- SAICAR synthetase (244 aa)
         
  0.708
purM
KEGG- hypothetical protein; K01933 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM- phosphoribosylformylglycinamidine cyclo-ligase; PFAM- AIR synthase related protein domain protein; AIR synthase related protein (352 aa)
         
  0.708
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine (462 aa)
         
  0.708
gch3
GTP cyclohydrolase III; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity (268 aa)
 
          0.641
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
Server load: low (9%) [HD]