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trpF protein (Methanococcus voltae) - STRING interaction network
"trpF" - PFAM: N-(5'phosphoribosyl)anthranilate isomerase in Methanococcus voltae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
trpFPFAM- N-(5’phosphoribosyl)anthranilate isomerase (PRAI); KEGG- mes-Meso_0667 N-(5’-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family (223 aa)    
Predicted Functional Partners:
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5’-phosphoribosyl)-anthranilate (PRA) (362 aa)
 
 
  0.999
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate; Belongs to the TrpA family (270 aa)
 
   
  0.998
Mvol_0580
KEGG- sat-SYN_02591 indole-3-glycerol phosphate synthase; PFAM- Indole-3-glycerol phosphate synthase (246 aa)
 
  0.998
Mvol_0577
KEGG- cff-CFF8240_0351 anthranilate synthase component II; TIGRFAM- glutamine amidotransferase of anthranilate synthase; PFAM- glutamine amidotransferase class-I (193 aa)
 
   
  0.998
trpE
Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (478 aa)
 
   
  0.995
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (399 aa)
 
   
  0.962
purL
Phosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought t [...] (740 aa)
   
   
  0.803
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family (338 aa)
   
   
  0.786
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (283 aa)
   
   
  0.771
hisE
KEGG- gem-GM21_3794 phosphoribosyl-ATP diphosphatase; TIGRFAM- phosphoribosyl-ATP diphosphatase; PFAM- phosphoribosyl-ATP pyrophosphohydrolase (100 aa)
 
   
  0.748
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
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