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cofG protein (Methanococcus voltae) - STRING interaction network
"cofG" - FO synthase subunit 1 in Methanococcus voltae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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cofGFO synthase subunit 1; Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (368 aa)    
Predicted Functional Partners:
cofH
FO synthase subunit 2; Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (355 aa)
   
  0.999
cofD
2-phospho-L-lactate transferase; Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5’)guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP (341 aa)
 
   
  0.971
purC
TIGRFAM- phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG- nam-NAMH_0651 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM- SAICAR synthetase (244 aa)
       
  0.926
mtrC
Tetrahydromethanopterin S-methyltransferase subunit C; Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step (263 aa)
           
  0.919
mtrE
Tetrahydromethanopterin S-methyltransferase subunit E; Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step (302 aa)
           
  0.919
cofC
2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5’-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family (256 aa)
 
     
  0.863
mptA
GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2’,3’-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin (311 aa)
         
  0.846
Mvol_0888
F420-dependent oxidoreductase; KEGG- eba-p2A347 hypothetical protein; TIGRFAM- F420-dependent oxidoreductase; PFAM- protein of unknown function DUF129 (257 aa)
 
   
  0.724
mtd
F420-dependent methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl- H(4)MPT(+) to methylene-H(4)MPT (277 aa)
           
  0.678
Mvol_1118
KEGG- bpy-Bphyt_4256 NADPH-dependent F420 reductase; TIGRFAM- NADPH-dependent F420 reductase; PFAM- NADP oxidoreductase coenzyme F420-dependent; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein (231 aa)
 
     
  0.666
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
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