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topA protein (Methanococcus voltae) - STRING interaction network
"topA" - DNA topoisomerase I in Methanococcus voltae
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA super [...] (828 aa)    
Predicted Functional Partners:
rpoA2
DNA-directed RNA polymerase subunit A’’; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (387 aa)
   
 
  0.997
Mvol_0217
RNA polymerase insert (188 aa)
   
 
  0.997
Mvol_1027
DNA-directed RNA polymerase subunit A’; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (888 aa)
     
 
  0.997
Mvol_0222
RNA polymerase Rpb6 (70 aa)
 
 
 
  0.986
radA
DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (322 aa)
 
  0.980
radB
AAA ATPase; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (280 aa)
   
  0.976
smc
Chromosome segregation protein SMC; Required for chromosome condensation and partitioning (1199 aa)
   
 
  0.972
Mvol_1013
tRNA/helicase-type nucleic acid-binding protein (643 aa)
 
  0.969
Mvol_0936
ERCC4 domain-containing protein (822 aa)
     
  0.964
Mvol_1508
Hypothetical protein (369 aa)
   
  0.959
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae, M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3, Methanococcus voltaei
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