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ilvC protein (Methanococcus voltae) - STRING interaction network
"ilvC" - Ketol-acid reductoisomerase in Methanococcus voltae
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ilvCKetol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate; Belongs to the ketol-acid reductoisomerase family (329 aa)    
Predicted Functional Partners:
ilvD
TIGRFAM- dihydroxy-acid dehydratase; KEGG- sat-SYN_01708 dihydroxy-acid dehydratase; PFAM- dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family (551 aa)
 
  0.999
Mvol_0274
KEGG- sfu-Sfum_3022 acetolactate synthase, small subunit; TIGRFAM- acetolactate synthase, small subunit; PFAM- Acetolactate synthase, small subunit-like; amino acid-binding ACT domain protein (169 aa)
 
  0.995
Mvol_0273
KEGG- geo-Geob_1509 acetolactate synthase, large subunit, biosynthetic type; TIGRFAM- acetolactate synthase, large subunit, biosynthetic type; PFAM- thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP-binding (601 aa)
 
 
  0.991
Mvol_1225
PFAM- thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG- bcc-BCc_139 IlvI; Belongs to the TPP enzyme family (552 aa)
 
 
  0.974
ilvE
Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family (286 aa)
   
 
  0.926
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (424 aa)
 
   
  0.844
Mvol_0791
TIGRFAM- isopropylmalate/isohomocitrate dehydrogenase; KEGG- aha-AHA_1152 isocitrate dehydrogenase; PFAM- isocitrate/isopropylmalate dehydrogenase (344 aa)
 
   
  0.822
Mvol_1671
3-isopropylmalate dehydratase, small subunit; KEGG- sat-SYN_00092 aconitase C-terminal domain-containing protein; TIGRFAM- 3-isopropylmalate dehydratase, small subunit; PFAM- aconitate hydratase domain protein (238 aa)
 
   
  0.819
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl- L-glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily (293 aa)
 
   
  0.706
cimA
Putative (R)-citramalate synthase CimA; Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family (529 aa)
   
   
  0.690
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
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