• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
pyrK protein (Methanococcus voltae) - STRING interaction network
"pyrK" - Probable dihydroorotate dehydrogenase B in Methanococcus voltae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrKProbable dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+) (260 aa)    
Predicted Functional Partners:
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate (319 aa)
  0.999
Mvol_0788
KEGG- bba-Bd2688 dihydroorotase; TIGRFAM- dihydroorotase, multifunctional complex type; PFAM- amidohydrolase (476 aa)
 
 
  0.974
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (184 aa)
       
  0.970
Mvol_0369
KEGG- nis-NIS_0367 anaerobic glycerol-3-phosphate dehydrogenase subunit C; TIGRFAM- succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM- protein of unknown function DUF224 cysteine-rich region domain protein; ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein (540 aa)
   
   
  0.892
pyrB
TIGRFAM- aspartate carbamoyltransferase; KEGG- vvu-VV1_1465 aspartate carbamoyltransferase catalytic subunit; PFAM- aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region (302 aa)
 
     
  0.744
Mvol_0759
KEGG- nam-NAMH_0054 orotidine 5’-phosphate decarboxylase; TIGRFAM- orotidine 5’-phosphate decarboxylase; PFAM- Orotidine 5’-phosphate decarboxylase; Belongs to the OMP decarboxylase family (217 aa)
   
   
  0.719
Mvol_1243
PFAM- 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG- dol-Dole_1308 hypothetical protein (169 aa)
   
 
  0.697
Mvol_1578
PFAM- ferredoxin; KEGG- geo-Geob_2544 ferredoxin (689 aa)
   
   
  0.687
Mvol_1670
SMART- DNA-directed DNA polymerase B; TIGRFAM- DNA polymerase Pol2; KEGG- DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; PFAM- DNA polymerase B region; DNA polymerase B exonuclease (879 aa)
   
   
  0.655
Mvol_1336
UPF0056 membrane protein; PFAM- multiple antibiotic resistance (MarC)-related protein; KEGG- mmb-Mmol_0625 multiple antibiotic resistance (MarC)-related protein (221 aa)
              0.601
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
Server load: low (9%) [HD]