Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
UPF0212 protein Mvol_1079; PFAM- Protein of unknown function DUF555; Belongs to the UPF0212 family (113 aa)
Predicted Functional Partners:
PFAM- Protein of unknown function DUF357 (110 aa)
PFAM- PfkB domain protein; KEGG- hha-Hhal_1195 ribokinase-like domain-containing protein; Belongs to the carbohydrate kinase PfkB family (316 aa)
ATP binding protein; KEGG- hypothetical protein; TIGRFAM- ATP binding protein; PFAM- protein of unknown function DUF71 ATP-binding region (223 aa)
tRNA (pseudouridine(54)-N(1))-methyltransferase; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family (205 aa)
PFAM- amino acid-binding ACT domain protein (160 aa)
Putative transcriptional regulatory protein Mvol_1427; Putative transcriptional regulator (146 aa)
Diadenylate cyclase; Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a putative second messenger in archaea (292 aa)