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pcn protein (Methanococcus voltae) - STRING interaction network
"pcn" - DNA polymerase sliding clamp in Methanococcus voltae
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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pcnDNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (269 aa)    
Predicted Functional Partners:
polB
DNA polymerase II small subunit; Possesses two activities- a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3’ to 5’ direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family (619 aa)
   
 
  0.998
thyA
Putative thymidylate synthase; May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily (213 aa)
     
 
  0.998
lig
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (597 aa)
   
 
  0.998
priS
DNA primase small subunit PriS; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthe [...] (369 aa)
 
   
  0.994
fen
Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. Binds the unpaired 3’-DNA end and kinks the DNA to facilitate 5’ cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (327 aa)
 
 
  0.991
priL
DNA primase large subunit PriL; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair (392 aa)
   
   
  0.989
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA- DNA hybrids; Belongs to the RNase HII family (264 aa)
 
 
  0.986
Mvol_1670
SMART- DNA-directed DNA polymerase B; TIGRFAM- DNA polymerase Pol2; KEGG- DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; PFAM- DNA polymerase B region; DNA polymerase B exonuclease (879 aa)
 
 
  0.979
Mvol_1508
KEGG- FHA domain protein (369 aa)
   
 
  0.961
rfcS
Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA (314 aa)
 
 
  0.956
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
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