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pan protein (Methanococcus voltae) - STRING interaction network
"pan" - 26S proteasome subunit P45 family in Methanococcus voltae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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pan26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a ’key in a lock’ to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...] (405 aa)    
Predicted Functional Partners:
psmB
Proteasome endopeptidase complex subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (215 aa)
     
  0.996
psmA
Proteasome endopeptidase complex subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (254 aa)
     
  0.996
rad50
SMC domain-containing protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex (1113 aa)
   
 
  0.991
Mvol_0035
SMC domain-containing protein (1113 aa)
   
 
  0.991
Mvol_1469
AAA family ATPase (781 aa)
   
0.980
smc
Chromosome segregation protein SMC; Required for chromosome condensation and partitioning (1199 aa)
   
 
  0.969
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (703 aa)
   
 
  0.936
Mvol_0316
Hypothetical protein (844 aa)
 
  0.905
eno
Enolase; Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (430 aa)
 
   
  0.899
Mvol_0674
Hypothetical protein (332 aa)
   
  0.887
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae, M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3, Methanococcus voltaei
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