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hisE protein (Methanococcus voltae) - STRING interaction network
"hisE" - KEGG: gem:GM21_3794 phosphoribosyl-ATP diphosphatase in Methanococcus voltae
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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hisEKEGG- gem-GM21_3794 phosphoribosyl-ATP diphosphatase; TIGRFAM- phosphoribosyl-ATP diphosphatase; PFAM- phosphoribosyl-ATP pyrophosphohydrolase (100 aa)    
Predicted Functional Partners:
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (127 aa)
   
  0.997
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (425 aa)
 
   
  0.982
hisB
KEGG- ppd-Ppro_3040 imidazoleglycerol-phosphate dehydratase; PFAM- imidazoleglycerol-phosphate dehydratase (190 aa)
 
   
  0.978
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity; Belongs to the ATP phosphoribosyltransferase family. Long subfamily (293 aa)
   
 
  0.975
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (283 aa)
 
   
  0.906
hisA
TIGRFAM- phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG- gur-Gura_4054 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM- histidine biosynthesis protein (242 aa)
 
   
  0.878
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family (138 aa)
              0.827
trpF
PFAM- N-(5’phosphoribosyl)anthranilate isomerase (PRAI); KEGG- mes-Meso_0667 N-(5’-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family (223 aa)
 
   
  0.748
hisC
KEGG- dal-Dalk_0935 histidinol-phosphate aminotransferase; TIGRFAM- histidinol-phosphate aminotransferase; PFAM- aminotransferase class I and II; aminotransferase class V (370 aa)
   
   
  0.682
pdxT
Pyridoxal 5’-phosphate synthase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5’-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS (192 aa)
              0.648
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
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