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polC protein (Methanococcus voltae) - STRING interaction network
"polC" - DNA polymerase II large subunit in Methanococcus voltae
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
polCDNA polymerase II large subunit; Possesses two activities- a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3’- to 5’-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (1206 aa)    
Predicted Functional Partners:
polB
DNA polymerase II small subunit; Possesses two activities- a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3’ to 5’ direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family (619 aa)
 
   
  0.996
Mvol_1467
KEGG- sat-SYN_01979 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM- anaerobic ribonucleoside-triphosphate reductase (772 aa)
       
    0.967
Mvol_1670
SMART- DNA-directed DNA polymerase B; TIGRFAM- DNA polymerase Pol2; KEGG- DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; PFAM- DNA polymerase B region; DNA polymerase B exonuclease (879 aa)
       
  0.935
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family (134 aa)
       
    0.911
dcd
Probable dCTP deaminase; TIGRFAM- deoxycytidine triphosphate deaminase; KEGG- msu-MS1581 deoxycytidine triphosphate deaminase; Belongs to the dCTP deaminase family (201 aa)
         
    0.900
tgtA
tRNA-guanine(15) transglycosylase; Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family (675 aa)
   
     
  0.769
Mvol_1161
KEGG- hypothetical protein; PFAM- PUA domain containing protein; SMART- PUA domain containing protein (636 aa)
   
     
  0.674
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (269 aa)
         
  0.661
Mvol_1284
PFAM- phosphoesterase RecJ domain protein; phosphoesterase DHHA1; KEGG- mes-Meso_0990 exonuclease RecJ (468 aa)
 
     
  0.638
Mvol_0931
PFAM- phosphoesterase DHHA1; phosphoesterase RecJ domain protein; KEGG- hypothetical protein (497 aa)
 
     
  0.638
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
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