• Version:
  • 11.0 (preview - - version 10.5 still available here)
STRINGSTRING
thiC protein (Methanococcus voltae) - STRING interaction network
"thiC" - Phosphomethylpyrimidine synthase in Methanococcus voltae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction; Belongs to the ThiC family (426 aa)    
Predicted Functional Partners:
Mvol_1254
KEGG- ech-ECH_0914 phosphomethylpyrimidine kinase; PFAM- Phosphomethylpyrimidine kinase type-1; Phosphomethylpyrimidine kinase (558 aa)
 
  0.994
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family (354 aa)
   
 
  0.966
thiE
Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP); Belongs to the thiamine-phosphate synthase family (206 aa)
   
  0.940
purM
KEGG- hypothetical protein; K01933 phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM- phosphoribosylformylglycinamidine cyclo-ligase; PFAM- AIR synthase related protein domain protein; AIR synthase related protein (352 aa)
   
 
  0.834
Mvol_1414
KEGG- dat-HRM2_15240 BioB2; PFAM- Radical SAM domain protein; SMART- Elongator protein 3/MiaB/NifB (360 aa)
   
 
  0.673
Mvol_1348
KEGG- dat-HRM2_15240 BioB2; PFAM- Radical SAM domain protein; SMART- Elongator protein 3/MiaB/NifB (382 aa)
   
 
  0.673
purE
N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (156 aa)
         
  0.672
Mvol_0150
Dephospho-CoA kinase-like protein; KEGG- hypothetical protein (188 aa)
         
  0.655
moaC
Probable cyclic pyranopterin monophosphate synthase; Catalyzes the conversion of (8S)-3’,8-cyclo-7,8- dihydroguanosine 5’-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family (165 aa)
         
  0.649
thi4
Thiamine thiazole synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur; Belongs to the THI4 family (266 aa)
   
   
  0.647
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
Server load: low (8%) [HD]