STRINGSTRING
top6A protein (Methanococcus voltae) - STRING interaction network
"top6A" - DNA topoisomerase in Methanococcus voltae
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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Experiments
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[Homology]
Score
top6ADNA topoisomerase; Relaxes both positive and negative superturns and exhibits a strong decatenase activity (365 aa)    
Predicted Functional Partners:
top6B
DNA topoisomerase VI subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity (658 aa)
 
  0.999
Mvol_0936
ERCC4 domain-containing protein (822 aa)
   
 
  0.951
rad50
SMC domain-containing protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex (1113 aa)
     
  0.950
Mvol_0035
SMC domain-containing protein (1113 aa)
     
  0.950
radA
DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (322 aa)
     
  0.936
radB
AAA ATPase; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (280 aa)
     
  0.936
mre11
Metallophosphoesterase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3’-5’ exonuclease activity and single- stranded endonuclease activity (391 aa)
     
  0.872
Mvol_0037
Metallophosphoesterase (391 aa)
     
  0.872
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. Binds the unpaired 3’-DNA end and kinks the DNA to facilitate 5’ cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] (327 aa)
     
 
  0.814
hisS
histidyl-tRNA synthetase (417 aa)
 
        0.715
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae, M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3, Methanococcus voltaei
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