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top6A protein (Methanococcus voltae) - STRING interaction network
"top6A" - Type 2 DNA topoisomerase 6 subunit A in Methanococcus voltae
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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Experiments
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[Homology]
Score
top6AType 2 DNA topoisomerase 6 subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family (365 aa)    
Predicted Functional Partners:
top6B
Type 2 DNA topoisomerase 6 subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity (658 aa)
 
 
  0.999
Mvol_1194
PFAM- CoA-binding domain protein; KEGG- dat-HRM2_16770 SucD3 (707 aa)
     
      0.992
radA
DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (322 aa)
 
 
  0.959
fen
Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. Binds the unpaired 3’-DNA end and kinks the DNA to facilitate 5’ cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (327 aa)
   
 
  0.854
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (269 aa)
 
   
  0.780
Mvol_0400
PFAM- Beta propeller domain; Proteinase inhibitor I42, chagasin; KEGG- ade-Adeh_1856 hypothetical protein (798 aa)
 
 
  0.752
rpl18
50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (194 aa)
   
     
  0.721
Mvol_0348
TIGRFAM- KH domain protein; PFAM- K Homology, type 1, subgroup; KEGG- predicted protein; K06961; SMART- KH domain protein (186 aa)
 
        0.704
rpoA2
DNA-directed RNA polymerase subunit A’’; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (387 aa)
   
     
  0.690
Mvol_0221
PFAM- RNA polymerase, N/8 Kd subunit; KEGG- DNA-directed RNA polymerase II 8.2 kDa polypeptide; K03007 DNA-directed RNA Polymerase II subunit L (68 aa)
   
     
  0.683
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
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