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rfcS protein (Methanococcus voltae) - STRING interaction network
"rfcS" - Replication factor C small subunit in Methanococcus voltae
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second shell of interactors
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some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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rfcSReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA (314 aa)    
Predicted Functional Partners:
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (269 aa)
 
 
  0.956
priS
DNA primase small subunit PriS; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthe [...] (369 aa)
   
 
  0.926
Mvol_1670
SMART- DNA-directed DNA polymerase B; TIGRFAM- DNA polymerase Pol2; KEGG- DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; PFAM- DNA polymerase B region; DNA polymerase B exonuclease (879 aa)
 
 
  0.840
radA
DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules (322 aa)
 
 
  0.840
Mvol_1401
MCM family protein; KEGG- hypothetical protein; K02212 minichromosome maintenance protein 4 (cell division control protein 54); PFAM- MCM family protein; magnesium chelatase ChlI subunit; SMART- MCM family protein; Belongs to the MCM family (687 aa)
 
 
  0.828
priL
DNA primase large subunit PriL; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair (392 aa)
   
 
  0.807
fen
Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. Binds the unpaired 3’-DNA end and kinks the DNA to facilitate 5’ cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (327 aa)
 
 
  0.798
Mvol_0842
MCM family protein; KEGG- DNA replication licensing factor mcm4; PFAM- MCM family protein; ATPase associated with various cellular activities AAA_5; magnesium chelatase ChlI subunit; SMART- MCM family protein; Belongs to the MCM family (716 aa)
 
 
  0.796
tfb
Transcription initiation factor IIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) (337 aa)
 
 
  0.791
topA
DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA super [...] (828 aa)
 
 
  0.781
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
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