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Mvol_1670 protein (Methanococcus voltae) - STRING interaction network
"Mvol_1670" - SMART: DNA-directed DNA polymerase B in Methanococcus voltae
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Mvol_1670SMART- DNA-directed DNA polymerase B; TIGRFAM- DNA polymerase Pol2; KEGG- DNA polymerase delta catalytic subunit; K02327 DNA polymerase delta subunit 1; PFAM- DNA polymerase B region; DNA polymerase B exonuclease (879 aa)    
Predicted Functional Partners:
polB
DNA polymerase II small subunit; Possesses two activities- a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3’ to 5’ direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family (619 aa)
     
  0.996
priL
DNA primase large subunit PriL; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair (392 aa)
   
 
  0.995
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (269 aa)
 
 
  0.979
priS
DNA primase small subunit PriS; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthe [...] (369 aa)
   
 
  0.975
polC
DNA polymerase II large subunit; Possesses two activities- a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3’- to 5’-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (1206 aa)
       
  0.935
fen
Flap endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. Binds the unpaired 3’-DNA end and kinks the DNA to facilitate 5’ cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...] (327 aa)
 
 
  0.924
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family (134 aa)
   
 
  0.908
Mvol_1467
KEGG- sat-SYN_01979 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM- anaerobic ribonucleoside-triphosphate reductase (772 aa)
     
 
    0.903
dcd
Probable dCTP deaminase; TIGRFAM- deoxycytidine triphosphate deaminase; KEGG- msu-MS1581 deoxycytidine triphosphate deaminase; Belongs to the dCTP deaminase family (201 aa)
       
    0.902
Mvol_1401
MCM family protein; KEGG- hypothetical protein; K02212 minichromosome maintenance protein 4 (cell division control protein 54); PFAM- MCM family protein; magnesium chelatase ChlI subunit; SMART- MCM family protein; Belongs to the MCM family (687 aa)
 
 
  0.893
Your Current Organism:
Methanococcus voltae
NCBI taxonomy Id: 456320
Other names: M. voltae A3, Methanococcus voltae, Methanococcus voltae A3, Methanococcus voltae str. A3, Methanococcus voltae strain A3
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