STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cofDLPPG; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (302 aa)    
Predicted Functional Partners:
Mboo_1380
TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129; KEGG: mhu:Mhun_0850 uncharacterised conserved protein UCP005026.
 
 
 0.986
Mboo_2190
TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129; KEGG: mhu:Mhun_0020 uncharacterised conserved protein UCP005026.
 
 
 0.986
cofC
Protein of unknown function DUF121; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
 
  
 0.982
cofG
Radical SAM domain protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
 
  
 0.979
mer
5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family.
 
   
 0.831
Mboo_1799
TIGRFAM: NADPH-dependent F420 reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent; KEGG: mhu:Mhun_3174 NADPH-dependent F420 reductase.
 
   
 0.800
Mboo_1416
KEGG: mhu:Mhun_0667 hypothetical protein.
 
     0.736
Mboo_0438
PFAM: protein phosphatase 2C domain protein; KEGG: mmc:Mmcs_0019 protein serine/threonine phosphatases.
  
  
 0.659
Mboo_1510
KEGG: ttj:TTHA1595 protein serine/threonine phosphatase.
  
  
 0.659
Mboo_0118
PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region; KEGG: mhu:Mhun_2443 metal dependent phosphohydrolase.
       0.613
Your Current Organism:
Methanoregula boonei
NCBI taxonomy Id: 456442
Other names: Candidatus Methanoregula boonei 6A8, M. boonei 6A8, Methanoregula boonei 6A8, Methanoregula boonei str. 6A8, Methanoregula boonei strain 6A8, methanogenic archaeon 6A8
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