node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mboo_1718 | hisA | Mboo_1718 | Mboo_1066 | PFAM: histidine biosynthesis; KEGG: mhu:Mhun_2630 histidine biosynthesis; Belongs to the HisA/HisF family. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | 0.923 |
Mboo_1718 | hisF | Mboo_1718 | Mboo_0659 | PFAM: histidine biosynthesis; KEGG: mhu:Mhun_2630 histidine biosynthesis; Belongs to the HisA/HisF family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.924 |
Mboo_1718 | hisH | Mboo_1718 | Mboo_1264 | PFAM: histidine biosynthesis; KEGG: mhu:Mhun_2630 histidine biosynthesis; Belongs to the HisA/HisF family. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.900 |
Mboo_1718 | hisI | Mboo_1718 | Mboo_1916 | PFAM: histidine biosynthesis; KEGG: mhu:Mhun_2630 histidine biosynthesis; Belongs to the HisA/HisF family. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.900 |
hisA | Mboo_1718 | Mboo_1066 | Mboo_1718 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | PFAM: histidine biosynthesis; KEGG: mhu:Mhun_2630 histidine biosynthesis; Belongs to the HisA/HisF family. | 0.923 |
hisA | hisB | Mboo_1066 | Mboo_1067 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sth:STH2836 imidazoleglycerol-phosphate dehydratase. | 0.999 |
hisA | hisC | Mboo_1066 | Mboo_2137 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | PFAM: aminotransferase, class I and II; KEGG: mhu:Mhun_2525 histidinol-phosphate aminotransferase. | 0.948 |
hisA | hisD | Mboo_1066 | Mboo_2149 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisA | hisE | Mboo_1066 | Mboo_2072 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mhu:Mhun_0790 phosphoribosyl-ATP pyrophosphohydrolase. | 0.997 |
hisA | hisF | Mboo_1066 | Mboo_0659 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Mboo_1066 | Mboo_0134 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.949 |
hisA | hisG-2 | Mboo_1066 | Mboo_1065 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.986 |
hisA | hisH | Mboo_1066 | Mboo_1264 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Mboo_1066 | Mboo_1916 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | Mboo_1067 | Mboo_1066 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sth:STH2836 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: mhu:Mhun_0921 histidine biosynthesis. | 0.999 |
hisB | hisC | Mboo_1067 | Mboo_2137 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sth:STH2836 imidazoleglycerol-phosphate dehydratase. | PFAM: aminotransferase, class I and II; KEGG: mhu:Mhun_2525 histidinol-phosphate aminotransferase. | 0.999 |
hisB | hisD | Mboo_1067 | Mboo_2149 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sth:STH2836 imidazoleglycerol-phosphate dehydratase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | Mboo_1067 | Mboo_2072 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sth:STH2836 imidazoleglycerol-phosphate dehydratase. | PFAM: MazG nucleotide pyrophosphohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mhu:Mhun_0790 phosphoribosyl-ATP pyrophosphohydrolase. | 0.997 |
hisB | hisF | Mboo_1067 | Mboo_0659 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sth:STH2836 imidazoleglycerol-phosphate dehydratase. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | Mboo_1067 | Mboo_0134 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: sth:STH2836 imidazoleglycerol-phosphate dehydratase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.954 |