STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cofCProtein of unknown function DUF121; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (214 aa)    
Predicted Functional Partners:
cofD
LPPG; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
 
  
 0.982
Mboo_2117
KEGG: mhu:Mhun_2976 thiamine pyrophosphate enzyme-like TPP-binding.
      
 0.895
mer
5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family.
 
   
 0.799
cofG
Radical SAM domain protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
 
   
 0.751
Mboo_1380
TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129; KEGG: mhu:Mhun_0850 uncharacterised conserved protein UCP005026.
 
   
 0.746
Mboo_0040
PFAM: Radical SAM domain protein; KEGG: mhu:Mhun_2970 hypothetical protein.
 
   
 0.743
Mboo_1799
TIGRFAM: NADPH-dependent F420 reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent; KEGG: mhu:Mhun_3174 NADPH-dependent F420 reductase.
 
   
 0.709
Mboo_2190
TIGRFAM: F420-dependent oxidoreductase, putative; PFAM: protein of unknown function DUF129; KEGG: mhu:Mhun_0020 uncharacterised conserved protein UCP005026.
 
   
 0.705
Mboo_1353
PFAM: amino acid-binding ACT domain protein; KEGG: mhu:Mhun_2293 amino acid-binding ACT.
  
     0.679
mfnB
Protein of unknown function DUF556; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
  
   
 0.664
Your Current Organism:
Methanoregula boonei
NCBI taxonomy Id: 456442
Other names: Candidatus Methanoregula boonei 6A8, M. boonei 6A8, Methanoregula boonei 6A8, Methanoregula boonei str. 6A8, Methanoregula boonei strain 6A8, methanogenic archaeon 6A8
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