STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemL1GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (425 aa)    
Predicted Functional Partners:
hemB
Delta-aminolevulinic acid dehydratase; Porphobilinogen synthase; ALAD; ALADH); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family.
 
 
 0.999
hemA
Glutamyl-tRNA reductase (GluTR); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
 0.997
hemC
Porphobilinogen deaminase (PBG; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.987
hemE
Uroporphyrinogen decarboxylase (URO-D; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the uroporphyrinogen decarboxylase family.
 
  
 0.978
hemN
Oxygen-independent coproporphyrinogen III oxidase (Coproporphyrinogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
 
   
 0.965
ABZ98135.1
Putative glutamate-1-semialdehyde 2,1-aminomutase, aminotransferase class-III (GSA); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.
 
  
 
0.927
hemL2
GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
  
 
0.922
hemG
Protoporphyrinogen oxidase (PPO); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
 
  
 0.916
hemH
Ferrochelatase (Protoheme ferro-lyase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.788
msrB
Peptide methionine sulfoxide reductase MsrB; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the MsrB Met sulfoxide reductase family.
       0.694
Your Current Organism:
Leptospira biflexa
NCBI taxonomy Id: 456481
Other names: L. biflexa serovar Patoc strain 'Patoc 1 (Paris)', Leptospira biflexa serovar Patoc str. ATCC 23582, Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)', Leptospira biflexa serovar Patoc strain Patoc 1
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.