node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABZ98130.1 | fmt | LEPBI_I2028 | LEPBI_I1657 | Putative methionyl-tRNA formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.919 |
ABZ98130.1 | folD | LEPBI_I2028 | LEPBI_I1723 | Putative methionyl-tRNA formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.958 |
ABZ98130.1 | gcvT | LEPBI_I2028 | LEPBI_I3188 | Putative methionyl-tRNA formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Aminomethyltransferase (Glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.916 |
ABZ98130.1 | glyA | LEPBI_I2028 | LEPBI_I1006 | Putative methionyl-tRNA formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Serine hydroxymethyltransferase (Serine methylase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.912 |
ABZ98130.1 | purN | LEPBI_I2028 | LEPBI_I1470 | Putative methionyl-tRNA formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.916 |
ABZ98130.1 | purT | LEPBI_I2028 | LEPBI_I2735 | Putative methionyl-tRNA formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
ABZ98130.1 | thyX | LEPBI_I2028 | LEPBI_I3300 | Putative methionyl-tRNA formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Thymidylate synthase ThyX (TS; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.912 |
ABZ98484.1 | folD | LEPBI_I2394 | LEPBI_I1723 | Putative 5-formyltetrahydrofolate cyclo-ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.934 |
ABZ98484.1 | purN | LEPBI_I2394 | LEPBI_I1470 | Putative 5-formyltetrahydrofolate cyclo-ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.916 |
ABZ98484.1 | purT | LEPBI_I2394 | LEPBI_I2735 | Putative 5-formyltetrahydrofolate cyclo-ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.906 |
fmt | ABZ98130.1 | LEPBI_I1657 | LEPBI_I2028 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Putative methionyl-tRNA formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.919 |
fmt | folD | LEPBI_I1657 | LEPBI_I1723 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.969 |
fmt | gcvT | LEPBI_I1657 | LEPBI_I3188 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Aminomethyltransferase (Glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine. | 0.916 |
fmt | glyA | LEPBI_I1657 | LEPBI_I1006 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase (Serine methylase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
fmt | purN | LEPBI_I1657 | LEPBI_I1470 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.926 |
fmt | purT | LEPBI_I1657 | LEPBI_I2735 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
fmt | thyX | LEPBI_I1657 | LEPBI_I3300 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Thymidylate synthase ThyX (TS; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.912 |
folD | ABZ98130.1 | LEPBI_I1723 | LEPBI_I2028 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative methionyl-tRNA formyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.958 |
folD | ABZ98484.1 | LEPBI_I1723 | LEPBI_I2394 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Putative 5-formyltetrahydrofolate cyclo-ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.934 |
folD | fmt | LEPBI_I1723 | LEPBI_I1657 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.969 |