node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABZ98038.1 | ABZ99370.1 | LEPBI_I1935 | LEPBI_I3305 | Putative histidyl-tRNA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.921 |
ABZ98038.1 | hisA | LEPBI_I1935 | LEPBI_I0876 | Putative histidyl-tRNA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.920 |
ABZ98038.1 | hisB | LEPBI_I1935 | LEPBI_I0874 | Putative histidyl-tRNA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Imidazoleglycerol-phosphate dehydratase (IGPD); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.939 |
ABZ98038.1 | hisC | LEPBI_I1935 | LEPBI_I1846 | Putative histidyl-tRNA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.907 |
ABZ98038.1 | hisD | LEPBI_I1935 | LEPBI_I1825 | Putative histidyl-tRNA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.927 |
ABZ98038.1 | hisE | LEPBI_I1935 | LEPBI_I0939 | Putative histidyl-tRNA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Phosphoribosyl-ATP pyrophosphatase (PRA-PH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.992 |
ABZ98038.1 | hisF | LEPBI_I1935 | LEPBI_I1729 | Putative histidyl-tRNA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.942 |
ABZ98038.1 | hisG | LEPBI_I1935 | LEPBI_I2593 | Putative histidyl-tRNA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.999 |
ABZ98038.1 | hisH | LEPBI_I1935 | LEPBI_I0875 | Putative histidyl-tRNA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.907 |
ABZ99370.1 | ABZ98038.1 | LEPBI_I3305 | LEPBI_I1935 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Putative histidyl-tRNA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.921 |
ABZ99370.1 | hisA | LEPBI_I3305 | LEPBI_I0876 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.998 |
ABZ99370.1 | hisB | LEPBI_I3305 | LEPBI_I0874 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazoleglycerol-phosphate dehydratase (IGPD); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.990 |
ABZ99370.1 | hisC | LEPBI_I3305 | LEPBI_I1846 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.981 |
ABZ99370.1 | hisD | LEPBI_I3305 | LEPBI_I1825 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.991 |
ABZ99370.1 | hisE | LEPBI_I3305 | LEPBI_I0939 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Phosphoribosyl-ATP pyrophosphatase (PRA-PH); Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.998 |
ABZ99370.1 | hisF | LEPBI_I3305 | LEPBI_I1729 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.991 |
ABZ99370.1 | hisG | LEPBI_I3305 | LEPBI_I2593 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.990 |
ABZ99370.1 | hisH | LEPBI_I3305 | LEPBI_I0875 | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.991 |
hisA | ABZ98038.1 | LEPBI_I0876 | LEPBI_I1935 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative histidyl-tRNA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.920 |
hisA | ABZ99370.1 | LEPBI_I0876 | LEPBI_I3305 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.998 |