node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABZ96787.1 | dcd | LEPBI_I0654 | LEPBI_I3246 | Putative nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase MazG; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.916 |
ABZ96787.1 | ndk | LEPBI_I0654 | LEPBI_I0084 | Putative nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase MazG; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.900 |
ABZ96787.1 | pyrF | LEPBI_I0654 | LEPBI_II0110 | Putative nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase MazG; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Orotidine-5'-monophosphate decarboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.900 |
ABZ96787.1 | pyrG | LEPBI_I0654 | LEPBI_I1645 | Putative nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase MazG; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | CTP synthase (UTP--ammonia ligase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.909 |
ABZ99313.1 | ABZ99314.1 | LEPBI_I3248 | LEPBI_I3249 | Hypothetical protein; Doubtful CDS. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.587 |
ABZ99313.1 | dcd | LEPBI_I3248 | LEPBI_I3246 | Hypothetical protein; Doubtful CDS. | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.829 |
ABZ99313.1 | fadB3 | LEPBI_I3248 | LEPBI_I3247 | Hypothetical protein; Doubtful CDS. | 3-hydroxyacyl-CoA dehydrogenase, NAD binding FadB; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.829 |
ABZ99314.1 | ABZ99313.1 | LEPBI_I3249 | LEPBI_I3248 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Hypothetical protein; Doubtful CDS. | 0.587 |
ABZ99314.1 | dcd | LEPBI_I3249 | LEPBI_I3246 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.738 |
ABZ99314.1 | fadB3 | LEPBI_I3249 | LEPBI_I3247 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 3-hydroxyacyl-CoA dehydrogenase, NAD binding FadB; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.740 |
coaD | dcd | LEPBI_I0086 | LEPBI_I3246 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.495 |
coaD | ndk | LEPBI_I0086 | LEPBI_I0084 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.762 |
dcd | ABZ96787.1 | LEPBI_I3246 | LEPBI_I0654 | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Putative nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase MazG; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | 0.916 |
dcd | ABZ99313.1 | LEPBI_I3246 | LEPBI_I3248 | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Hypothetical protein; Doubtful CDS. | 0.829 |
dcd | ABZ99314.1 | LEPBI_I3246 | LEPBI_I3249 | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.738 |
dcd | coaD | LEPBI_I3246 | LEPBI_I0086 | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.495 |
dcd | dut | LEPBI_I3246 | LEPBI_I1531 | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.926 |
dcd | fadB3 | LEPBI_I3246 | LEPBI_I3247 | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 3-hydroxyacyl-CoA dehydrogenase, NAD binding FadB; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.862 |
dcd | metG | LEPBI_I3246 | LEPBI_I3307 | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Methionyl-tRNA synthetase (Methionine--tRNA ligase); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.443 |
dcd | ndk | LEPBI_I3246 | LEPBI_I0084 | Deoxycytidine triphosphate deaminase (dCTP deaminase); Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.927 |