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hisZ protein (Ruminococcus sp. 5139BFAA) - STRING interaction network
"hisZ" - ATP phosphoribosyltransferase regulatory subunit in Ruminococcus sp. 5139BFAA
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisZATP phosphoribosyltransferase regulatory subunit ; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (372 aa)    
Predicted Functional Partners:
hisG
ATP phosphoribosyltransferase ; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (215 aa)
 
  0.999
hisI
Phosphoribosyl-AMP cyclohydrolase ; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (117 aa)
       
  0.913
hisD
Histidinol dehydrogenase ; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (434 aa)
 
     
  0.909
hisF
ImGP synthase subunit HisF ; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (252 aa)
       
  0.779
hisB
Imidazoleglycerol-phosphate dehydratase (195 aa)
   
   
  0.757
RSAG_00514
Histidine-tRNA ligase (418 aa)
   
 
0.743
RSAG_02650
Ribose-phosphate diphosphokinase (395 aa)
     
 
    0.743
RSAG_00626
Ribose-phosphate diphosphokinase (416 aa)
     
 
    0.743
hisH
ImGP synthase subunit HisH ; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (212 aa)
 
   
  0.541
RSAG_00734
Histidinol phosphate phosphatase HisJ family protein (272 aa)
 
     
  0.521
Your Current Organism:
Ruminococcus sp. 5139BFAA
NCBI taxonomy Id: 457412
Other names: R. sp. 5_1_39BFAA, Ruminococcus 5_1_39BFAA, Ruminococcus sp. 5139BFAA, Ruminococcus sp. 5_1_39BFAA
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