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ligA protein (Ruminococcus sp. 5139BFAA) - STRING interaction network
"ligA" - Polydeoxyribonucleotide synthase [NAD(+)] in Ruminococcus sp. 5139BFAA
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ligAPolydeoxyribonucleotide synthase [NAD(+)] ; DNA ligase that catalyzes the formation of phosphodiester linkages between 5’-phosphoryl and 3’-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (614 aa)    
Predicted Functional Partners:
RSAG_00234
No annotation available (323 aa)
 
 
    0.951
RSAG_02429
DNA helicase (744 aa)
 
   
  0.824
metA
Homoserine O-transsuccinylase (310 aa)
              0.813
uvrB
Excinuclease ABC subunit B ; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (662 aa)
 
 
  0.785
dnaG
DNA primase ; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication (598 aa)
 
   
  0.767
gyrA
DNA gyrase subunit A ; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (857 aa)
   
   
  0.756
RSAG_01228
DNA polymerase I (849 aa)
 
 
  0.756
RSAG_03049
DNA topoisomerase (ATP-hydrolyzing) (748 aa)
   
   
  0.748
RSAG_03307
DNA polymerase III subunit beta ; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3’ to 5’ exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (371 aa)
   
  0.695
lysS
Lysyl-tRNA synthetase (678 aa)
   
   
  0.680
Your Current Organism:
Ruminococcus sp. 5139BFAA
NCBI taxonomy Id: 457412
Other names: R. sp. 5_1_39BFAA, Ruminococcus 5_1_39BFAA, Ruminococcus sp. 5139BFAA, Ruminococcus sp. 5_1_39BFAA
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