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hisH protein (Ruminococcus sp. 5139BFAA) - STRING interaction network
"hisH" - ImGP synthase subunit HisH in Ruminococcus sp. 5139BFAA
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Score
hisHImGP synthase subunit HisH ; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (212 aa)    
Predicted Functional Partners:
hisF
ImGP synthase subunit HisF ; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (252 aa)
  0.999
hisB
Imidazoleglycerol-phosphate dehydratase (195 aa)
 
 
  0.992
hisD
Histidinol dehydrogenase ; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (434 aa)
 
   
  0.987
hisI
Phosphoribosyl-AMP cyclohydrolase ; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (117 aa)
 
 
  0.987
hisG
ATP phosphoribosyltransferase ; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (215 aa)
 
   
  0.970
RSAG_02227
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (255 aa)
   
 
  0.952
hisC
Imidazole acetol-phosphate transaminase (351 aa)
 
 
  0.941
RSAG_01279
Threonine-phosphate decarboxylase (347 aa)
 
 
  0.927
RSAG_01223
Histidinol-phosphate transaminase (363 aa)
 
 
  0.925
RSAG_01852
Uncharacterized protein (394 aa)
   
 
  0.874
Your Current Organism:
Ruminococcus sp. 5139BFAA
NCBI taxonomy Id: 457412
Other names: R. sp. 5_1_39BFAA, Ruminococcus 5_1_39BFAA, Ruminococcus sp. 5139BFAA, Ruminococcus sp. 5_1_39BFAA
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