STRINGSTRING
glyA protein (Ruminococcus sp. 5139BFAA) - STRING interaction network
"glyA" - Serine hydroxymethyltransferase in Ruminococcus sp. 5139BFAA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glyASerine hydroxymethyltransferase ; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (412 aa)    
Predicted Functional Partners:
RSAG_01852
Uncharacterized protein (394 aa)
   
  0.988
folD
Bifunctional protein FolD ; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (284 aa)
 
  0.978
RSAG_03267
RpiB/LacA/LacB family sugar-phosphate isomerase (143 aa)
   
      0.958
purD
Phosphoribosylglycinamide synthetase (424 aa)
   
 
  0.919
fhs
Formyltetrahydrofolate synthetase (561 aa)
   
  0.917
purC
SAICAR synthetase (294 aa)
   
 
  0.912
RSAG_02887
Phosphoribosylformylglycinamidine synthase (1254 aa)
   
   
  0.907
purN
GAR transformylase ; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate (213 aa)
   
 
  0.904
purM
Phosphoribosyl-aminoimidazole synthetase (341 aa)
     
 
  0.889
RSAG_03066
FolC protein (427 aa)
   
  0.870
Your Current Organism:
Ruminococcus sp. 5139BFAA
NCBI taxonomy Id: 457412
Other names: R. sp. 5_1_39BFAA, Ruminococcus 5_1_39BFAA, Ruminococcus sp. 5139BFAA, Ruminococcus sp. 5_1_39BFAA
Server load: low (12%) [HD]