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RSAG_01873 protein (Ruminococcus sp. 5139BFAA) - STRING interaction network
"RSAG_01873" - Dihydrofolate reductase in Ruminococcus sp. 5139BFAA
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RSAG_01873Dihydrofolate reductase ; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (163 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase ; Provides the sole de novo source of dTMP for DNA biosynthesis (282 aa)
 
  0.999
RSAG_01313
7,8-dihydroneopterin aldolase ; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin (283 aa)
 
 
  0.938
RSAG_00700
Riboflavin biosynthesis protein RibD ; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5’-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5’-phosphate (375 aa)
   
   
  0.897
RSAG_01314
Dihydropteroate pyrophosphorylase ; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives (271 aa)
   
 
  0.876
RSAG_02826
FolC protein (432 aa)
 
  0.868
RSAG_03066
FolC protein (427 aa)
   
  0.850
glyA
Serine hydroxymethyltransferase ; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (412 aa)
   
  0.829
RSAG_03268
Uncharacterized protein (163 aa)
   
 
    0.811
fhs
Formyltetrahydrofolate synthetase (561 aa)
   
 
  0.783
fmt
Methionyl-tRNA formyltransferase ; Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by- (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (324 aa)
   
 
  0.771
Your Current Organism:
Ruminococcus sp. 5139BFAA
NCBI taxonomy Id: 457412
Other names: R. sp. 5_1_39BFAA, Ruminococcus 5_1_39BFAA, Ruminococcus sp. 5139BFAA, Ruminococcus sp. 5_1_39BFAA
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