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lepA protein (Ruminococcus sp. 5139BFAA) - STRING interaction network
"lepA" - Ribosomal back-translocase LepA in Ruminococcus sp. 5139BFAA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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lepARibosomal back-translocase LepA ; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (602 aa)    
Predicted Functional Partners:
prfA
Peptide chain release factor 1 ; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (358 aa)
 
   
  0.866
pheS
Phenylalanyl-tRNA synthetase alpha subunit (341 aa)
   
   
  0.807
RSAG_02145
Uncharacterized protein (380 aa)
 
   
  0.802
rplM
50S ribosomal protein L13 ; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (142 aa)
 
 
  0.791
dnaK
Heat shock protein 70 ; Acts as a chaperone (625 aa)
 
   
  0.735
obg
GTP-binding protein Obg ; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control (434 aa)
   
   
  0.724
gidA
Glucose-inhibited division protein A ; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (634 aa)
 
   
  0.718
RSAG_01355
Uncharacterized protein (1517 aa)
   
   
  0.697
der
GTP-binding protein EngA ; GTPase that plays an essential role in the late steps of ribosome biogenesis (441 aa)
   
 
  0.680
rpsE
30S ribosomal protein S5 ; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (169 aa)
   
 
  0.670
Your Current Organism:
Ruminococcus sp. 5139BFAA
NCBI taxonomy Id: 457412
Other names: R. sp. 5_1_39BFAA, Ruminococcus 5_1_39BFAA, Ruminococcus sp. 5139BFAA, Ruminococcus sp. 5_1_39BFAA
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