STRINGSTRING
nth protein (Ruminococcus sp. 5139BFAA) - STRING interaction network
"nth" - DNA-(apurinic or apyrimidinic site) lyase in Ruminococcus sp. 5139BFAA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthDNA-(apurinic or apyrimidinic site) lyase ; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination, leaving a 3’-terminal unsaturated sugar and a product with a terminal 5’-phosphate (215 aa)    
Predicted Functional Partners:
RSAG_03032
Exodeoxyribonuclease III (Xth) (251 aa)
 
 
  0.977
RSAG_01096
Endonuclease IV ; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5’-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (272 aa)
   
 
  0.786
RSAG_00951
Endonuclease IV ; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5’-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (278 aa)
   
 
  0.786
RSAG_01228
DNA polymerase I (849 aa)
 
 
  0.765
RSAG_01646
Methionine--tRNA ligase ; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (652 aa)
   
   
  0.676
ung
Uracil-DNA glycosylase ; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (224 aa)
     
 
  0.660
recO
Recombination protein O ; Involved in DNA repair and RecF pathway recombination (247 aa)
       
 
  0.653
der
GTP-binding protein EngA ; GTPase that plays an essential role in the late steps of ribosome biogenesis (441 aa)
   
   
  0.649
RSAG_01176
Exonuclease SbcCD, D subunit (1275 aa)
     
 
  0.647
RSAG_04639
Phosphopyruvate hydratase (301 aa)
         
  0.636
Your Current Organism:
Ruminococcus sp. 5139BFAA
NCBI taxonomy Id: 457412
Other names: R. sp. 5_1_39BFAA, Ruminococcus 5_1_39BFAA, Ruminococcus sp. 5139BFAA, Ruminococcus sp. 5_1_39BFAA
Server load: low (9%) [HD]