node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACB84024.1 | fhs | Nther_0428 | Nther_0083 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: aoe:Clos_2127 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.942 |
ACB84024.1 | fmt | Nther_0428 | Nther_1334 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.907 |
ACB84024.1 | folD | Nther_0428 | Nther_1700 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+), Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.978 |
ACB84024.1 | gcvT | Nther_0428 | Nther_2751 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.917 |
ACB84024.1 | purH | Nther_0428 | Nther_0458 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | KEGG: oih:OB0749 IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.902 |
ACB84024.1 | purN | Nther_0428 | Nther_0457 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.905 |
ACB84274.1 | fhs | Nther_0681 | Nther_0083 | PFAM: methylenetetrahydrofolate reductase; KEGG: drm:Dred_2192 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: aoe:Clos_2127 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.673 |
ACB84274.1 | folD | Nther_0681 | Nther_1700 | PFAM: methylenetetrahydrofolate reductase; KEGG: drm:Dred_2192 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+), Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.964 |
ACB84274.1 | gcvT | Nther_0681 | Nther_2751 | PFAM: methylenetetrahydrofolate reductase; KEGG: drm:Dred_2192 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.932 |
ACB84274.1 | glyA | Nther_0681 | Nther_2858 | PFAM: methylenetetrahydrofolate reductase; KEGG: drm:Dred_2192 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
fhs | ACB84024.1 | Nther_0083 | Nther_0428 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: aoe:Clos_2127 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | 0.942 |
fhs | ACB84274.1 | Nther_0083 | Nther_0681 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: aoe:Clos_2127 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: methylenetetrahydrofolate reductase; KEGG: drm:Dred_2192 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.673 |
fhs | fmt | Nther_0083 | Nther_1334 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: aoe:Clos_2127 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.514 |
fhs | folD | Nther_0083 | Nther_1700 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: aoe:Clos_2127 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+), Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
fhs | gcvT | Nther_0083 | Nther_2751 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: aoe:Clos_2127 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.941 |
fhs | glyA | Nther_0083 | Nther_2858 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: aoe:Clos_2127 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |
fhs | purD | Nther_0083 | Nther_0459 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: aoe:Clos_2127 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: tex:Teth514_0526 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family. | 0.593 |
fhs | purH | Nther_0083 | Nther_0458 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: aoe:Clos_2127 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: oih:OB0749 IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.983 |
fhs | purN | Nther_0083 | Nther_0457 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: aoe:Clos_2127 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.970 |
fmt | ACB84024.1 | Nther_1334 | Nther_0428 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: amt:Amet_4589 formiminotransferase-cyclodeaminase. | 0.907 |