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ITPase protein (Zea mays) - STRING interaction network
"ITPase" - LOC100283993 in Zea mays
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ITPaseLOC100283993 ; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5’-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (201 aa)    
Predicted Functional Partners:
pco144935
Hypothetical protein LOC100193051 ; Plays an important role in the de novo pathway of purine nucleotide biosynthesis (489 aa)
   
 
  0.868
PURA
Adenylosuccinate synthetase, chloroplastic Precursor (AMPSase)(AdSS)(EC 6.3.4.4)(IMP--aspartate ligase); Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity) (484 aa)
   
 
  0.868
GRMZM2G421493_P01
Bifunctional dihydrofolate reductase-thymidylate synthase-like (440 aa)
   
 
  0.824
Zm.96157
Bifunctional dihydrofolate reductase-thymidylate synthase ; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (562 aa)
   
 
  0.824
GRMZM2G072608_P01
Uncharacterized protein (300 aa)
   
 
  0.824
DRTS
Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes Dihydrofolate reductase(EC 1.5.1.3);Thymidylate synthase(EC 2.1.1.45)]; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate- de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (B [...] (523 aa)
   
 
  0.824
Zm.141574
Calmodulin-binding transcription activator 1-like (1025 aa)
           
  0.710
Zm.20620
Zinc phosphodiesterase ELAC protein 2-like (930 aa)
   
 
  0.629
GRMZM5G802566_P06
Hypothetical protein LOC100217092 (492 aa)
   
 
  0.628
GRMZM2G121460_P01
Uncharacterized protein (308 aa)
     
      0.625
Your Current Organism:
Zea mays
NCBI taxonomy Id: 4577
Other names: Euchlaena, Z. mays, Zea, Zea L., Zea mays, Zea mays L., Zea mays var. japonica, maize
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