Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Groups of genes that are frequently observed in each other's genomic neighborhood.
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Bowman-Birk type wound-induced proteinase inhibitor WIP1 (102 aa)
Predicted Functional Partners:
Benzoxazinone synthesis14; O-methyltransferase ZRP4; Uncharacterized protein ; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O- methyltransferase family (366 aa)
Zeamatin; Has antifungal activity. Inhibits Candida albicans and Trichoderma reesei; marginal inhibition observed against Alternaria solani and Neurospora crassa (227 aa)
Chitinase2 (261 aa)
Acidic endochitinase (312 aa)
Putative serine type endopeptidase inhibitor (78 aa)