Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Genes that are sometimes fused into single open reading frames.
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
empty nodes: proteins of unknown 3D structure
filled nodes: some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
from curated databases
Glutaredoxin-C13 (105 aa)
Predicted Functional Partners:
Thioredoxin reductase ; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family (523 aa)
Putative RING zinc finger domain superfamily protein; RING finger and CHY zinc finger domain-containing protein 1; Uncharacterized protein (293 aa)
Glutathione reductase cytosolic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family (495 aa)
Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (835 aa)
Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (815 aa)
1-Cys peroxiredoxin PER1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (By similarity). Seems to contribute to the inhibition of germination during stress (By similarity); Belongs to the peroxiredoxin family. Prx6 subfamily (252 aa)