STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)    
Predicted Functional Partners:
Shal_3462
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.952
Shal_4064
TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; KEGG: par:Psyc_0401 probable C-5 cytosine-specific DNA methylase.
    
 0.932
Shal_2751
Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: saz:Sama_1242 methionine gamma-lyase.
   
 0.927
Shal_1804
PFAM: S-adenosylmethionine decarboxylase; KEGG: spc:Sputcn32_1648 adenosylmethionine decarboxylase.
   
 
 0.926
Shal_2212
Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: sfr:Sfri_2024 aspartate transaminase.
     
 0.906
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
  
 
 0.905
Shal_0610
dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family.
    
  0.900
Shal_2366
PFAM: GAF domain protein; KEGG: saz:Sama_1583 GAF domain-containing protein.
    
  0.900
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
 
  
 0.863
Shal_0624
KEGG: slo:Shew_0522 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
  
 0.855
Your Current Organism:
Shewanella halifaxensis
NCBI taxonomy Id: 458817
Other names: S. halifaxensis HAW-EB4, Shewanella halifaxensis HAW-EB4, Shewanella halifaxensis str. HAW-EB4, Shewanella halifaxensis strain HAW-EB4
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