node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Shal_0624 | folD | Shal_0624 | Shal_2770 | KEGG: slo:Shew_0522 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.934 |
Shal_0624 | gcvT | Shal_0624 | Shal_3375 | KEGG: slo:Shew_0522 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.936 |
Shal_0624 | glyA | Shal_0624 | Shal_1203 | KEGG: slo:Shew_0522 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.956 |
Shal_0624 | thyA | Shal_0624 | Shal_1070 | KEGG: slo:Shew_0522 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.927 |
Shal_0910 | Shal_3351 | Shal_0910 | Shal_3351 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | 0.456 |
Shal_0910 | gcvT | Shal_0910 | Shal_3375 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.920 |
Shal_0910 | glyA | Shal_0910 | Shal_1203 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.929 |
Shal_0910 | thyA | Shal_0910 | Shal_1070 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.997 |
Shal_3351 | Shal_0910 | Shal_3351 | Shal_0910 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.456 |
Shal_3351 | dut | Shal_3351 | Shal_0427 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.946 |
Shal_3351 | tdk | Shal_3351 | Shal_2941 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | PFAM: thymidine kinase; KEGG: slo:Shew_2579 thymidine kinase. | 0.941 |
Shal_3351 | thyA | Shal_3351 | Shal_1070 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.946 |
Shal_3351 | tmk | Shal_3351 | Shal_2376 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.933 |
Shal_3407 | gcvT | Shal_3407 | Shal_3375 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: vvu:VV2_1034 dihydrofolate reductase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.599 |
Shal_3407 | thyA | Shal_3407 | Shal_1070 | PFAM: bifunctional deaminase-reductase domain protein; KEGG: vvu:VV2_1034 dihydrofolate reductase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.932 |
dut | Shal_3351 | Shal_0427 | Shal_3351 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: slo:Shew_3055 CMP/dCMP deaminase, zinc-binding. | 0.946 |
dut | tdk | Shal_0427 | Shal_2941 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | PFAM: thymidine kinase; KEGG: slo:Shew_2579 thymidine kinase. | 0.980 |
dut | thyA | Shal_0427 | Shal_1070 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.975 |
dut | tmk | Shal_0427 | Shal_2376 | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.945 |
folD | Shal_0624 | Shal_2770 | Shal_0624 | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | KEGG: slo:Shew_0522 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.934 |