node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Shal_0328 | Shal_0641 | Shal_0328 | Shal_0641 | PFAM: aldehyde dehydrogenase; KEGG: shm:Shewmr7_3772 aldehyde dehydrogenase (NAD(+)); Belongs to the aldehyde dehydrogenase family. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | 0.505 |
Shal_0328 | Shal_2089 | Shal_0328 | Shal_2089 | PFAM: aldehyde dehydrogenase; KEGG: shm:Shewmr7_3772 aldehyde dehydrogenase (NAD(+)); Belongs to the aldehyde dehydrogenase family. | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 0.906 |
Shal_0328 | Shal_2250 | Shal_0328 | Shal_2250 | PFAM: aldehyde dehydrogenase; KEGG: shm:Shewmr7_3772 aldehyde dehydrogenase (NAD(+)); Belongs to the aldehyde dehydrogenase family. | PFAM: iron-containing alcohol dehydrogenase; aldehyde dehydrogenase; KEGG: slo:Shew_1910 iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.915 |
Shal_0328 | acsA | Shal_0328 | Shal_1697 | PFAM: aldehyde dehydrogenase; KEGG: shm:Shewmr7_3772 aldehyde dehydrogenase (NAD(+)); Belongs to the aldehyde dehydrogenase family. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.936 |
Shal_0641 | Shal_0328 | Shal_0641 | Shal_0328 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | PFAM: aldehyde dehydrogenase; KEGG: shm:Shewmr7_3772 aldehyde dehydrogenase (NAD(+)); Belongs to the aldehyde dehydrogenase family. | 0.505 |
Shal_0641 | Shal_2088 | Shal_0641 | Shal_2088 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | Pyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 0.623 |
Shal_0641 | Shal_2089 | Shal_0641 | Shal_2089 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 0.918 |
Shal_0641 | Shal_2122 | Shal_0641 | Shal_2122 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | KEGG: pha:PSHAa0897 nonspecific lipid-transfer protein. | 0.940 |
Shal_0641 | Shal_2250 | Shal_0641 | Shal_2250 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | PFAM: iron-containing alcohol dehydrogenase; aldehyde dehydrogenase; KEGG: slo:Shew_1910 iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.980 |
Shal_0641 | Shal_2596 | Shal_0641 | Shal_2596 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.985 |
Shal_0641 | Shal_2737 | Shal_0641 | Shal_2737 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. | 0.985 |
Shal_0641 | acsA | Shal_0641 | Shal_1697 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.966 |
Shal_0641 | leuA | Shal_0641 | Shal_0438 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.960 |
Shal_2088 | Shal_0641 | Shal_2088 | Shal_0641 | Pyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | 0.623 |
Shal_2088 | Shal_2089 | Shal_2088 | Shal_2089 | Pyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | 0.999 |
Shal_2088 | Shal_2090 | Shal_2088 | Shal_2090 | Pyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | PFAM: Hydratase/decarboxylase; KEGG: pha:PSHAa2141 2-hydroxypent-2,4-dienoate hydratase (HPH) (2-oxopent-4-enoate hydratase). | 0.994 |
Shal_2088 | Shal_2250 | Shal_2088 | Shal_2250 | Pyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | PFAM: iron-containing alcohol dehydrogenase; aldehyde dehydrogenase; KEGG: slo:Shew_1910 iron-containing alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.625 |
Shal_2089 | Shal_0328 | Shal_2089 | Shal_0328 | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | PFAM: aldehyde dehydrogenase; KEGG: shm:Shewmr7_3772 aldehyde dehydrogenase (NAD(+)); Belongs to the aldehyde dehydrogenase family. | 0.906 |
Shal_2089 | Shal_0641 | Shal_2089 | Shal_0641 | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rpc:RPC_0704 pyruvate flavodoxin/ferredoxin oxidoreductase-like. | 0.918 |
Shal_2089 | Shal_2088 | Shal_2089 | Shal_2088 | Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. | Pyruvate carboxyltransferase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. | 0.999 |