STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (153 aa)    
Predicted Functional Partners:
Shal_0706
PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: slo:Shew_3218 carbamoyl-phosphate synthase L chain, ATP-binding.
 
  
 0.999
lpxA
acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
 
  
 0.995
Shal_1777
3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
 
 0.974
Shal_0367
TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase, putative; PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: shw:Sputw3181_0286 3-oxoacyl-(acyl-carrier-protein) reductase, putative.
 
 0.959
Shal_2747
PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: ppr:PBPRB1562 hypothetical 3-oxoacyl-(acyl carrier protein) reductase.
 
 0.957
lpxD
UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
 
  
 0.956
fabA
Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
  
 
 0.953
Shal_2872
PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: shm:Shewmr7_2658 short-chain dehydrogenase/reductase SDR.
 
 0.952
Shal_1776
TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: son:SO_2777 malonyl CoA-acyl carrier protein transacylase.
 
  
 0.948
Shal_1779
Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
 
 0.942
Your Current Organism:
Shewanella halifaxensis
NCBI taxonomy Id: 458817
Other names: S. halifaxensis HAW-EB4, Shewanella halifaxensis HAW-EB4, Shewanella halifaxensis str. HAW-EB4, Shewanella halifaxensis strain HAW-EB4
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