node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Shal_0910 | Shal_3462 | Shal_0910 | Shal_3462 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.922 |
Shal_0910 | fhs | Shal_0910 | Shal_3806 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: spc:Sputcn32_3314 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.928 |
Shal_0910 | gcvT | Shal_0910 | Shal_3375 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.920 |
Shal_0910 | glyA | Shal_0910 | Shal_1203 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.929 |
Shal_0910 | purH | Shal_0910 | Shal_0488 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | KEGG: slo:Shew_3412 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.921 |
Shal_0910 | purN | Shal_0910 | Shal_1679 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.920 |
Shal_0910 | purT | Shal_0910 | Shal_0924 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
Shal_3462 | Shal_0910 | Shal_3462 | Shal_0910 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.922 |
Shal_3462 | fhs | Shal_3462 | Shal_3806 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: spc:Sputcn32_3314 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.952 |
Shal_3462 | folD | Shal_3462 | Shal_2770 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.535 |
Shal_3462 | gcvT | Shal_3462 | Shal_3375 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.955 |
Shal_3462 | glyA | Shal_3462 | Shal_1203 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
Shal_3462 | purH | Shal_3462 | Shal_0488 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: slo:Shew_3412 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.911 |
Shal_3462 | purN | Shal_3462 | Shal_1679 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.925 |
Shal_3462 | purT | Shal_3462 | Shal_0924 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.900 |
fhs | Shal_0910 | Shal_3806 | Shal_0910 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: spc:Sputcn32_3314 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.928 |
fhs | Shal_3462 | Shal_3806 | Shal_3462 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: spc:Sputcn32_3314 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.952 |
fhs | folD | Shal_3806 | Shal_2770 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: spc:Sputcn32_3314 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.996 |
fhs | gcvT | Shal_3806 | Shal_3375 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: spc:Sputcn32_3314 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.949 |
fhs | glyA | Shal_3806 | Shal_1203 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: spc:Sputcn32_3314 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.971 |