node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
bacA | dnaK | ETA_29170 | ETA_07050 | Similar to bacitracin synthetase 1 (BA1), protein contains non-ribosomal peptide synthetase modules; silverDB:etchr02904. | Chaperone protein dnaK (Heat shock 70 kDa protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.507 |
bacA | gntY | ETA_29170 | ETA_32280 | Similar to bacitracin synthetase 1 (BA1), protein contains non-ribosomal peptide synthetase modules; silverDB:etchr02904. | Putative membrane-bound protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.574 |
bacA | iscS | ETA_29170 | ETA_10200 | Similar to bacitracin synthetase 1 (BA1), protein contains non-ribosomal peptide synthetase modules; silverDB:etchr02904. | Cysteine desulfurase (NifS protein homolog); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.764 |
bacA | sseA | ETA_29170 | ETA_10230 | Similar to bacitracin synthetase 1 (BA1), protein contains non-ribosomal peptide synthetase modules; silverDB:etchr02904. | 3-mercaptopyruvate:cyanide sulfurtransferase; silverDB:etchr01014. | 0.425 |
bacA | thiI | ETA_29170 | ETA_25240 | Similar to bacitracin synthetase 1 (BA1), protein contains non-ribosomal peptide synthetase modules; silverDB:etchr02904. | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.797 |
dnaK | bacA | ETA_07050 | ETA_29170 | Chaperone protein dnaK (Heat shock 70 kDa protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Similar to bacitracin synthetase 1 (BA1), protein contains non-ribosomal peptide synthetase modules; silverDB:etchr02904. | 0.507 |
dnaK | gntY | ETA_07050 | ETA_32280 | Chaperone protein dnaK (Heat shock 70 kDa protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Putative membrane-bound protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.520 |
dnaK | iscR | ETA_07050 | ETA_10190 | Chaperone protein dnaK (Heat shock 70 kDa protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Predicted transcriptional regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.429 |
dnaK | iscS | ETA_07050 | ETA_10200 | Chaperone protein dnaK (Heat shock 70 kDa protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Cysteine desulfurase (NifS protein homolog); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.758 |
dnaK | sufA | ETA_07050 | ETA_18200 | Chaperone protein dnaK (Heat shock 70 kDa protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Iron-sulfur cluster assembly scaffold protein; silverDB:etchr01809; Belongs to the HesB/IscA family. | 0.646 |
gntY | bacA | ETA_32280 | ETA_29170 | Putative membrane-bound protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | Similar to bacitracin synthetase 1 (BA1), protein contains non-ribosomal peptide synthetase modules; silverDB:etchr02904. | 0.574 |
gntY | dnaK | ETA_32280 | ETA_07050 | Putative membrane-bound protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | Chaperone protein dnaK (Heat shock 70 kDa protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.520 |
gntY | iscR | ETA_32280 | ETA_10190 | Putative membrane-bound protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | Predicted transcriptional regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.646 |
gntY | iscS | ETA_32280 | ETA_10200 | Putative membrane-bound protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | Cysteine desulfurase (NifS protein homolog); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.942 |
gntY | sufA | ETA_32280 | ETA_18200 | Putative membrane-bound protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | Iron-sulfur cluster assembly scaffold protein; silverDB:etchr01809; Belongs to the HesB/IscA family. | 0.600 |
gntY | thiI | ETA_32280 | ETA_25240 | Putative membrane-bound protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. | 0.560 |
iscR | dnaK | ETA_10190 | ETA_07050 | Predicted transcriptional regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Chaperone protein dnaK (Heat shock 70 kDa protein); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.429 |
iscR | gntY | ETA_10190 | ETA_32280 | Predicted transcriptional regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Putative membrane-bound protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.646 |
iscR | iscS | ETA_10190 | ETA_10200 | Predicted transcriptional regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Cysteine desulfurase (NifS protein homolog); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.942 |
iscR | sufA | ETA_10190 | ETA_18200 | Predicted transcriptional regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Iron-sulfur cluster assembly scaffold protein; silverDB:etchr01809; Belongs to the HesB/IscA family. | 0.729 |