node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS22944.1 | polA | GWCH70_0002 | GWCH70_2673 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.990 |
ACS22944.1 | rnhB | GWCH70_0002 | GWCH70_1096 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.885 |
ACS22944.1 | thyA | GWCH70_0002 | GWCH70_1581 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.804 |
ACS23954.1 | ACS23957.1 | GWCH70_1094 | GWCH70_1097 | KEGG: gtn:GTNG_1056 type I signal peptidase; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; Belongs to the peptidase S26 family. | KEGG: gtn:GTNG_1059 hypothetical protein. | 0.568 |
ACS23954.1 | ACS23958.1 | GWCH70_1094 | GWCH70_1098 | KEGG: gtn:GTNG_1056 type I signal peptidase; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; Belongs to the peptidase S26 family. | KEGG: gtn:GTNG_1060 flagellar biosynthesis. | 0.542 |
ACS23954.1 | rbgA | GWCH70_1094 | GWCH70_1095 | KEGG: gtn:GTNG_1056 type I signal peptidase; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; Belongs to the peptidase S26 family. | GTP-binding protein HSR1-related; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. Binds to the 23S rRNA (By similarity). Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. | 0.779 |
ACS23954.1 | rnhB | GWCH70_1094 | GWCH70_1096 | KEGG: gtn:GTNG_1056 type I signal peptidase; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; Belongs to the peptidase S26 family. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.787 |
ACS23957.1 | ACS23954.1 | GWCH70_1097 | GWCH70_1094 | KEGG: gtn:GTNG_1059 hypothetical protein. | KEGG: gtn:GTNG_1056 type I signal peptidase; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; Belongs to the peptidase S26 family. | 0.568 |
ACS23957.1 | ACS23958.1 | GWCH70_1097 | GWCH70_1098 | KEGG: gtn:GTNG_1059 hypothetical protein. | KEGG: gtn:GTNG_1060 flagellar biosynthesis. | 0.789 |
ACS23957.1 | acpP | GWCH70_1097 | GWCH70_1082 | KEGG: gtn:GTNG_1059 hypothetical protein. | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.559 |
ACS23957.1 | rbgA | GWCH70_1097 | GWCH70_1095 | KEGG: gtn:GTNG_1059 hypothetical protein. | GTP-binding protein HSR1-related; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. Binds to the 23S rRNA (By similarity). Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. | 0.618 |
ACS23957.1 | rnhB | GWCH70_1097 | GWCH70_1096 | KEGG: gtn:GTNG_1059 hypothetical protein. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.806 |
ACS23958.1 | ACS23954.1 | GWCH70_1098 | GWCH70_1094 | KEGG: gtn:GTNG_1060 flagellar biosynthesis. | KEGG: gtn:GTNG_1056 type I signal peptidase; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein; Belongs to the peptidase S26 family. | 0.542 |
ACS23958.1 | ACS23957.1 | GWCH70_1098 | GWCH70_1097 | KEGG: gtn:GTNG_1060 flagellar biosynthesis. | KEGG: gtn:GTNG_1059 hypothetical protein. | 0.789 |
ACS23958.1 | rbgA | GWCH70_1098 | GWCH70_1095 | KEGG: gtn:GTNG_1060 flagellar biosynthesis. | GTP-binding protein HSR1-related; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. Binds to the 23S rRNA (By similarity). Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. | 0.629 |
ACS23958.1 | rnhB | GWCH70_1098 | GWCH70_1096 | KEGG: gtn:GTNG_1060 flagellar biosynthesis. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.843 |
ACS24113.1 | polA | GWCH70_1261 | GWCH70_2673 | KEGG: gka:GK1351 hypothetical protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.564 |
ACS24113.1 | rnhB | GWCH70_1261 | GWCH70_1096 | KEGG: gka:GK1351 hypothetical protein. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.781 |
acpP | ACS23957.1 | GWCH70_1082 | GWCH70_1097 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | KEGG: gtn:GTNG_1059 hypothetical protein. | 0.559 |
acpP | dnaJ | GWCH70_1082 | GWCH70_2436 | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.898 |